the asus eee netbook works with the special netbook edition of ubuntu - but they have awful keyboards. The desktop ubuntu will work with most PC specs you throw at it, i've not had any issues yet but others have (but then windows vista and 7 are in exactly the same boat here). Yes I would check out the laptop first to see if there any any issues, but there probably won't be, and you can boot ubuntu from cd to try it without installing anything.
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